HitPredict

Interactor 1: CDC42 (P60766)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PAR6B (Q9JK83)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: Pard6b

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	10934474
Identification Methods	coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity GO:0045177 - apical part of cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Mm			1 371
+	Hs
		564670 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAR6B_HUMAN (1-371): 1.74e-133: 387: 91.40
+	Hs
		1316964 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAR6B_HUMAN (1-371): 1.74e-133: 387: 91.40
+	Hs
		925587 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6B_HUMAN (1-371): 1.74e-133: 387: 91.40
+	Hs
		894391 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PAR6B_HUMAN (1-371): 1.74e-133: 387: 91.40
+	Hs
		1316959 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAR6G_HUMAN (1-371): 1.26e-120: 355: 56.84
+	Hs
		925586 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6G_HUMAN (1-371): 1.26e-120: 355: 56.84
+	Hs
		894390 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PAR6G_HUMAN (1-371): 1.26e-120: 355: 56.84
+	Hs
		564698 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAR6A_HUMAN (1-328): 2.87e-96: 292: 50.60
+	Hs
		925642 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6A_HUMAN (1-328): 2.87e-96: 292: 50.60
+	Hs
		894470 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PAR6A_HUMAN (1-328): 2.87e-96: 292: 50.60
+	Hs
		159153 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		CSKP_HUMAN (71-354): 4.28e-66: 226: 16.23
+	Hs
		159267 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		CSKP_HUMAN (71-354): 4.28e-66: 226: 16.23
+	Hs
		159189 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		CSKP_HUMAN (71-354): 4.28e-66: 226: 16.23
+	Hs
		159184 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		CSKP_HUMAN (71-354): 4.28e-66: 226: 16.23
+	Hs
		564561 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MPP7_HUMAN (48-343): 1.59e-52: 185: 14.80
+	Hs
		1132891 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MPP7_HUMAN (48-343): 1.59e-52: 185: 14.80
+	Hs
		925341 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MPP7_HUMAN (48-343): 1.59e-52: 185: 14.80
+	Hs
		894107 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MPP7_HUMAN (48-343): 1.59e-52: 185: 14.80
+	Hs
		894207 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PALS1_HUMAN (82-356): 9.43e-48: 173: 17.65
+	Hs
		564636 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DLG3_HUMAN (159-239): 8.29e-11: 65.4: 32.10