HitPredict

Interactor 1: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Interactor 2: EIF3C (Q99613)
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)
Gene: EIF3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 29395067, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0006413 - translational initiation
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 913
+	Hs
		1051905 IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32		EIF3C_HUMAN (1-913): 0: 1213: 100.00
+	Hs
		78275 DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71		EIFCL_HUMAN (1-913): 0: 1209: 99.13
+	Sc
		485678 IF4A_YEAST (20-406): 8.01e-168: 477: 66.41		EIF3C_YEAST (5-256): 8.62e-18: 90.6: 21.53