HitPredict

Interactor 1: IF4A1 (P60843)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: Eif4a1

Interactor 2: IF4G1 (Q6NZJ6)
Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1)
Gene: Eif4g1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	16541103, 19153607
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DEAD~MA3, DEAD~MIF4G, Helicase_C~MA3, Helicase_C~MIF4G
Common GO terms	GO:0003743 - translation initiation factor activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006413 - translational initiation GO:0016281 - eukaryotic translation initiation factor 4F complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 1600
+	Hs
		979902 IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32		IF4G1_HUMAN (1-1599): 0: 890: 88.64
+	Hs
		757578 IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75		IF4G1_HUMAN (1-1599): 0: 890: 88.64
+	Hs
		892779 IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00		IF4G1_HUMAN (1-1599): 0: 890: 88.64
+	Hs
		203371 IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32		IF4G3_HUMAN (41-1599): 0: 733: 42.54
+	Hs
		203355 IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00		IF4G3_HUMAN (41-1599): 0: 733: 42.54
+	Hs
		941985 IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32		IF4G2_HUMAN (728-1589): 0: 618: 24.94
+	Dm
		247403 IF4A_DROME (6-406): 0: 517: 72.95		O61380_DROME (5-1591): 1.77e-162: 538: 21.81
+	Hs
		892776 IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00		IF4G2_HUMAN (728-1589): 0: 618: 24.94
+	Dm
		972132 IF4A_DROME (6-406): 0: 517: 72.95		Q5KTT4_DROME (1100-1599): 1.25e-81: 299: 18.98
+	Dm
		972167 IF4A_DROME (6-406): 0: 517: 72.95		Q9VY91_DROME (1047-1516): 2.09e-84: 288: 10.44
+	At
		1275773 IF4A3_ARATH (17-406): 1.16e-130: 383: 70.51		IF4G1_ARATH (589-1392): 6.81e-114: 381: 22.87
+	Hs
		1051874 IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32		PDCD4_HUMAN (1081-1517): 3.72e-90: 303: 14.83
+	Sc
		485737 IF4A_YEAST (20-406): 8.01e-168: 477: 66.41		IF4F2_YEAST (277-1092): 7.17e-73: 265: 19.41
+	Sc
		485736 IF4A_YEAST (20-406): 8.01e-168: 477: 66.41		IF4F1_YEAST (282-1047): 5.33e-71: 260: 19.26
+	Hs
		757641 IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75		PDCD4_HUMAN (1081-1517): 3.72e-90: 303: 14.83
+	Mm
		892950 IF4A1_MOUSE (1-406): 1.84e-132: 387: 100.00		PDCD4_MOUSE (1081-1517): 4.61e-92: 309: 15.06
+	Hs
		892823 IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00		PDCD4_HUMAN (1081-1517): 3.72e-90: 303: 14.83
+	Sc
		624098 DBP2_YEAST (2-404): 8.49e-137: 403: 31.63		IF4F1_YEAST (282-1047): 5.33e-71: 260: 19.26
+	Hs
		892899 IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00		PAIP1_HUMAN (637-994): 4.12e-54: 199: 21.69
+	Sc
		761940 DHH1_YEAST (32-402): 1.41e-99: 307: 44.47		IF4F1_YEAST (282-1047): 5.33e-71: 260: 19.26