HitPredict

Interactor 1: SEM1 (P60896)
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)
Gene: SEM1

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	16239144, 15610744, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 70 Hs			1 406
+	Hs
		893529 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		798625 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730227 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		893531 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64