HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome and 1 others more... GO:0072686 - mitotic spindle
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 445
+	Hs
		925258 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		1046579 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Rn
		1109026 RAC1_RAT (1-191): 1.75e-84: 249: 70.31		TBB2B_RAT (1-430): 0: 710: 98.14
+	Hs
		893979 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		428118 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		428120 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		900366 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Bt
		900343 RHOA_BOVIN (5-191): 3.88e-81: 240: 53.48		TBB2B_BOVIN (1-430): 0: 710: 98.14
+	Hs
		381156 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TBB4A_HUMAN (1-427): 0: 706: 98.60
+	Hs
		950983 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Hs
		900852 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		1046499 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		TBB2A_HUMAN (1-430): 0: 707: 97.67