HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18426980
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 4655
+	Hs
		564477 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		925190 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		900376 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		254256 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90
+	Hs
		270329 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30
+	Hs
		258347 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258305 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258303 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258304 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258292 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		270285 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30
+	Hs
		258302 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42