HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: BORG5 (Q00587)
Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)
Gene: CDC42EP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	25416956, 16189514, 32296183, 31980649, 31871319, 35271311, 20936779, 21988832, unassigned1304, unassigned2173
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0031274 - positive regulation of pseudopodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 391
+	Hs
		564481 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		960657 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		925198 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		950927 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		900382 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		545325 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		436256 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		892320 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		564682 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		1330288 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		925610 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		894420 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		951333 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		900891 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		545611 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		150121 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG1_HUMAN (33-217): 2.72e-53: 177: 32.09
+	Hs
		564729 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG2_HUMAN (33-218): 6.27e-48: 165: 27.85
+	Hs
		150124 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG1_HUMAN (33-217): 2.72e-53: 177: 32.09
+	Hs
		894571 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG2_HUMAN (33-218): 6.27e-48: 165: 27.85
+	Hs
		894139 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG3_HUMAN (38-67): 9.1e-09: 55.7: 86.67