HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1038
+	Hs
		564520 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BMPR2_HUMAN (1-1038): 0: 868: 100.00
+	Hs
		1046386 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BMPR2_HUMAN (1-1038): 0: 868: 100.00
+	Hs
		925266 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BMPR2_HUMAN (1-1038): 0: 868: 100.00
+	Hs
		950982 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BMPR2_HUMAN (1-1038): 0: 868: 100.00
+	Hs
		900458 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BMPR2_HUMAN (1-1038): 0: 868: 100.00
+	Mm
		1143794 RHOJ_MOUSE (2-179): 1.33e-84: 250: 65.17		TGFR2_MOUSE (8-504): 1.23e-137: 427: 30.19
+	Hs
		738409 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75
+	Hs
		738321 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75
+	Hs
		564416 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		AVR2A_HUMAN (11-515): 1.01e-122: 386: 32.49
+	Hs
		738322 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75
+	Hs
		739935 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TGFR2_HUMAN (8-521): 1.09e-118: 378: 29.66
+	Hs
		564434 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30
+	Hs
		738577 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30
+	Hs
		738521 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30
+	Hs
		738516 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30
+	Hs
		738527 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30
+	Mm
		1142495 RHOJ_MOUSE (2-179): 1.33e-84: 250: 65.17		ACVL1_MOUSE (49-512): 9.74e-107: 344: 29.80
+	Hs
		738517 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30
+	Mm
		983316 RAC2_MOUSE (1-191): 1.1e-80: 239: 69.27		ACVL1_MOUSE (49-512): 9.74e-107: 344: 29.80
+	Hs
		738490 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ACV1B_HUMAN (59-512): 3.73e-101: 329: 29.07