HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PDE3A (Q14432)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Gene: PDE3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1141
+	Hs
		950995 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		900467 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		545375 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		893966 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		950967 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		900437 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		545353 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		436286 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		238071 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PDE8A_HUMAN (607-1050): 1.62e-130: 420: 23.34
+	Hs
		238058 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PDE8A_HUMAN (607-1050): 1.62e-130: 420: 23.34
+	Hs
		238054 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		PDE8A_HUMAN (607-1050): 1.62e-130: 420: 23.34
+	Hs
		845963 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PDE6C_HUMAN (594-1065): 3.83e-117: 385: 20.70