HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31871319, 15306850
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 776
+	Hs
		564535 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ARHG6_HUMAN (1-776): 0: 621: 100.00
+	Hs
		1066050 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ARHG6_HUMAN (1-776): 0: 621: 100.00
+	Hs
		925289 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARHG6_HUMAN (1-776): 0: 621: 100.00
+	Gg
		1141019 Q6LC82_CHICK (1-191): 1.75e-84: 249: 70.31		ARHG6_CHICK (1-775): 0: 589: 73.55
+	Hs
		564524 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		1049733 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		925271 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22
+	Hs
		548678 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		VAV_HUMAN (1-746): 1.59e-120: 384: 16.20
+	Hs
		855782 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		VAV2_HUMAN (1-746): 1.37e-111: 361: 15.14
+	Hs
		925527 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SPT13_HUMAN (100-638): 8.39e-103: 332: 17.54
+	Hs
		50555 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		564737 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PKHG1_HUMAN (179-720): 1.21e-80: 284: 19.53
+	Ce
		975575 RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97		VAV_CAEEL (2-724): 3.34e-86: 295: 15.59
+	Hs
		925382 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PREX2_HUMAN (220-543): 5.59e-83: 291: 21.39
+	Hs
		925455 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PREX1_HUMAN (218-552): 8.7e-83: 291: 23.40
+	Hs
		50617 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		50580 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80
+	Hs
		925405 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARHGP_HUMAN (218-656): 3.19e-79: 267: 18.87
+	Hs
		224711 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		KALRN_HUMAN (203-772): 1.73e-74: 266: 17.83
+	Hs
		279854 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TRIO_HUMAN (230-567): 1.42e-72: 261: 20.46