HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PLCB4 (Q15147)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
Gene: PLCB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1175
+	Hs
		564537 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		1068532 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		925291 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		951009 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		900491 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		545390 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		436313 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		892383 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		PLCB4_HUMAN (1-1175): 0: 1180: 100.00
+	Hs
		925200 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PLCB2_HUMAN (9-1169): 0: 999: 33.90
+	Hs
		900537 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PLCH1_HUMAN (15-924): 0: 788: 26.19
+	Hs
		580973 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58
+	Hs
		580968 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58
+	Hs
		581019 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58
+	Hs
		925208 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PLCB3_HUMAN (835-1076): 2.9e-12: 73.6: 12.35
+	Hs
		545329 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		PLCB3_HUMAN (835-1076): 2.9e-12: 73.6: 12.35