HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: RHG31 (Q2M1Z3)
Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)
Gene: ARHGAP31

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1444
+	Hs
		63073 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG42_HUMAN (37-475): 3.48e-86: 303: 19.40
+	Hs
		64652 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG32_HUMAN (1-881): 7.08e-75: 278: 27.77
+	Hs
		564562 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG21_HUMAN (6-531): 1.1e-70: 264: 20.32
+	Hs
		64741 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG32_HUMAN (1-881): 7.08e-75: 278: 27.77
+	Hs
		64688 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG32_HUMAN (1-881): 7.08e-75: 278: 27.77
+	Mm
		1194500 RHOJ_MOUSE (2-179): 1.33e-84: 250: 65.17		RHG33_MOUSE (1-901): 1.24e-72: 269: 27.10
+	Hs
		1133703 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG21_HUMAN (6-531): 1.1e-70: 264: 20.32
+	Hs
		147862 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG33_HUMAN (1-891): 6.83e-71: 263: 25.82
+	Mm
		925805 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG22_MOUSE (7-438): 1.68e-69: 250: 17.35
+	Hs
		564503 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG05_HUMAN (8-243): 1.37e-58: 224: 21.94
+	Mm
		925802 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		CHIO_MOUSE (2-216): 9.9e-70: 239: 29.63
+	Hs
		1330939 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG35_HUMAN (11-240): 7.58e-59: 226: 24.24
+	Hs
		1022689 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG05_HUMAN (8-243): 1.37e-58: 224: 21.94
+	Hs
		253311 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		SRGP2_HUMAN (28-582): 1.39e-52: 204: 15.21
+	Hs
		564492 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG01_HUMAN (16-221): 1.54e-55: 202: 26.32
+	Mm
		925793 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		ABR_MOUSE (1-229): 1.08e-55: 212: 30.51
+	Hs
		993069 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG01_HUMAN (16-221): 1.54e-55: 202: 26.32
+	Mm
		925803 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG32_MOUSE (1-1241): 9.25e-52: 203: 19.92
+	Mm
		925791 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG01_MOUSE (16-220): 4.73e-55: 201: 26.44
+	Mm
		925798 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		BCR_MOUSE (8-186): 1.2e-18: 94.7: 31.67