HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: Q4LE69 (Q4LE69)
1-phosphatidylinositol 4-kinase (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 2121
+	Hs
		564555 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1117795 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		925325 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		951044 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		900539 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		545417 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		436341 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		892405 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1117760 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		564440 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Hs
		128832 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		P3C2A_HUMAN (1411-2120): 1.91e-150: 512: 17.85
+	Hs
		128833 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		P3C2A_HUMAN (1411-2120): 1.91e-150: 512: 17.85
+	Hs
		128803 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		P3C2A_HUMAN (1411-2120): 1.91e-150: 512: 17.85
+	Hs
		787203 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Hs
		128876 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		P3C2A_HUMAN (1411-2120): 1.91e-150: 512: 17.85
+	Hs
		787196 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Mm
		925806 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		PK3CB_MOUSE (1465-2118): 2.73e-140: 468: 18.62
+	Mm
		892731 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		PK3CB_MOUSE (1465-2118): 2.73e-140: 468: 18.62
+	Mm
		951511 RHOG_MOUSE (1-191): 7.59e-82: 242: 60.73		PK3CB_MOUSE (1465-2118): 2.73e-140: 468: 18.62
+	Hs
		900702 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PK3C3_HUMAN (1415-2117): 8.86e-127: 424: 17.26