HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1121
+	Hs
		564690 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		1330924 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		925629 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Mm
		925805 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG22_MOUSE (143-801): 9.06e-60: 220: 15.26
+	Hs
		925394 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG22_HUMAN (139-801): 2.51e-55: 207: 14.66
+	Hs
		894168 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		RHG22_HUMAN (139-801): 2.51e-55: 207: 14.66
+	Hs
		125140 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Mm
		56825 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		SMUF2_MOUSE (3-213): 6.72e-48: 185: 18.18
+	Hs
		125711 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Hs
		876341 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		125349 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Hs
		125298 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Hs
		925616 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		894431 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		1299636 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		564644 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		1294861 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		925520 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		808080 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		894313 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49