HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PREX1 (Q8TCU6)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)
Gene: PREX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.825

The method score is based on:

Property Details
Experiments 32203420, 27150042
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, x-ray crystallography, molecular sieving
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ras~RhoGEF
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0030335 - positive regulation of cell migration
GO:1900026 - positive regulation of substrate adhesion-dependent cell spreading
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 191
Hs

1 1659
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024