HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: GWL (Q96GX5)
Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)
Gene: MASTL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31478661
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 879
+	Hs
		564425 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		AKT2_HUMAN (439-877): 2.2e-105: 336: 17.60
+	Hs
		681775 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AKT1_HUMAN (492-877): 9.23e-103: 329: 18.34
+	Hs
		564418 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MARK3_HUMAN (533-864): 1.5e-92: 310: 13.82
+	Hs
		564584 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MARK2_HUMAN (536-861): 1.42e-91: 308: 11.98
+	Hs
		647958 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MARK3_HUMAN (533-864): 1.5e-92: 310: 13.82
+	Hs
		1183120 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MARK2_HUMAN (536-861): 1.42e-91: 308: 11.98
+	Hs
		647868 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MARK3_HUMAN (533-864): 1.5e-92: 310: 13.82
+	Hs
		925384 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MARK2_HUMAN (536-861): 1.42e-91: 308: 11.98
+	Hs
		647856 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MARK3_HUMAN (533-864): 1.5e-92: 310: 13.82
+	Hs
		647872 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		MARK3_HUMAN (533-864): 1.5e-92: 310: 13.82
+	Hs
		894157 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MARK2_HUMAN (536-861): 1.42e-91: 308: 11.98
+	Hs
		894319 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MARK4_HUMAN (555-864): 8.73e-91: 305: 16.04
+	Hs
		564514 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ROCK1_HUMAN (700-865): 1.35e-37: 154: 27.07
+	Hs
		1035206 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ROCK1_HUMAN (700-865): 1.35e-37: 154: 27.07
+	Hs
		925253 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ROCK1_HUMAN (700-865): 1.35e-37: 154: 27.07
+	Hs
		893975 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ROCK1_HUMAN (700-865): 1.35e-37: 154: 27.07
+	Hs
		950974 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		ROCK1_HUMAN (700-865): 1.35e-37: 154: 27.07
+	Hs
		850711 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		KS6A3_HUMAN (740-870): 1.09e-17: 90.1: 36.23
+	Hs
		850632 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		KS6A3_HUMAN (740-870): 1.09e-17: 90.1: 36.23
+	Hs
		616691 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		KS6B1_HUMAN (740-870): 8.65e-17: 86.7: 34.78