HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: GDIR3 (Q99819)
Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma)
Gene: ARHGDIG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9113980
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 225
+	Hs
		925561 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Hs
		951270 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Hs
		900840 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Mm
		925816 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		GDIR1_MOUSE (36-225): 6.84e-105: 302: 60.53
+	Hs
		854769 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854760 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Rn
		901290 RHOA_RAT (5-191): 9.99e-82: 242: 53.48		GDIR1_RAT (36-225): 6.84e-105: 302: 60.53
+	Hs
		854771 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854763 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		545278 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		436218 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854851 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Hs
		854852 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Hs
		545279 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	At
		1105129 RAC3_ARATH (2-180): 4.54e-84: 248: 56.43		GDIR_ARATH (27-223): 4.23e-80: 241: 28.64
+	Ce
		975573 RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97		GDIR_CAEEL (47-222): 9.12e-76: 228: 37.29
+	Ce
		983036 CDC42_CAEEL (1-191): 1.83e-79: 236: 86.39		GDIR_CAEEL (47-222): 9.12e-76: 228: 37.29
+	Cl
		47354 RAC1_CANLF (1-191): 1.75e-84: 249: 70.31		A0A8I3N6C6_CANLF (36-225): 9.11e-70: 212: 44.21
+	Sc
		580337 CDC42_YEAST (1-191): 2.69e-80: 238: 80.11		GDIR_YEAST (47-222): 8.14e-70: 213: 36.41
+	Ca
		483031 CDC42_CANAL (1-191): 6.02e-79: 235: 76.96		Q5AND4_CANAL (38-221): 8.41e-70: 213: 35.20