HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PAR6G (Q9BYG4)
Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)
Gene: PARD6G

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	31871319, 11260256, 14676191
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 376
+	Hs
		1316959 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAR6G_HUMAN (1-376): 7.02e-146: 419: 100.00
+	Hs
		925586 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6G_HUMAN (1-376): 7.02e-146: 419: 100.00
+	Hs
		564670 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAR6B_HUMAN (1-376): 1.3e-120: 355: 54.55
+	Hs
		1316964 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAR6B_HUMAN (1-376): 1.3e-120: 355: 54.55
+	Hs
		925587 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6B_HUMAN (1-376): 1.3e-120: 355: 54.55
+	Mm
		892735 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		PAR6B_MOUSE (1-376): 2.65e-121: 356: 55.18
+	Hs
		894391 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PAR6B_HUMAN (1-376): 1.3e-120: 355: 54.55
+	Hs
		564698 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAR6A_HUMAN (17-343): 7.05e-92: 281: 51.06
+	Hs
		925642 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6A_HUMAN (17-343): 7.05e-92: 281: 51.06
+	Hs
		894470 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PAR6A_HUMAN (17-343): 7.05e-92: 281: 51.06
+	Dm
		332600 RAC1_DROME (1-191): 1.02e-81: 242: 69.27		O97111_DROME (15-318): 2.14e-89: 274: 52.29
+	Hs
		159153 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		CSKP_HUMAN (70-342): 1.79e-60: 211: 17.48
+	Hs
		159267 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		CSKP_HUMAN (70-342): 1.79e-60: 211: 17.48
+	Hs
		564561 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MPP7_HUMAN (37-327): 3.53e-57: 197: 17.22
+	Hs
		159189 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		CSKP_HUMAN (70-342): 1.79e-60: 211: 17.48
+	Hs
		159184 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		CSKP_HUMAN (70-342): 1.79e-60: 211: 17.48
+	Hs
		1132891 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MPP7_HUMAN (37-327): 3.53e-57: 197: 17.22
+	Hs
		925341 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MPP7_HUMAN (37-327): 3.53e-57: 197: 17.22
+	Hs
		894107 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MPP7_HUMAN (37-327): 3.53e-57: 197: 17.22
+	Hs
		894207 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PALS1_HUMAN (25-327): 1.91e-48: 175: 19.94