HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PAR6B (Q9BYG5)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: PARD6B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.982

Property	Details
Experiments	25416956, 32296183, 10934474, 31871319, 20936779, 23439680, 11260256, 14676191, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid, coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 372
+	Hs
		564670 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		1316964 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Mm
		892735 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		PAR6B_MOUSE (1-372): 2.86e-154: 440: 91.40
+	Hs
		925587 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		1316959 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		925586 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		564698 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		925642 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		159153 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		159267 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		159189 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		159184 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		564561 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		1132891 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		925341 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		894107 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MPP7_HUMAN (48-306): 4.59e-36: 140: 16.92
+	Hs
		564526 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Hs
		1050061 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Hs
		925273 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Hs
		893999 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83