HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0016020 - membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 889
+	Hs
		564672 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1317980 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		925589 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		951303 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		900866 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		564655 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		545575 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		1330915 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		925615 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		951338 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		900901 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		925582 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		894383 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		951289 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		564667 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		900859 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		925581 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		951288 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		900858 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		545592 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62