HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: E41L1 (Q9H4G0)
Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)
Gene: EPB41L1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 881
+	Hs
		564684 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		E41L1_HUMAN (1-881): 0: 718: 100.00
+	Hs
		1330914 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		E41L1_HUMAN (1-881): 0: 718: 100.00
+	Hs
		925613 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		E41L1_HUMAN (1-881): 0: 718: 100.00
+	Mm
		250712 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		E41L2_MOUSE (3-865): 0: 558: 42.52
+	Hs
		564694 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		E41L5_HUMAN (60-763): 1.14e-151: 465: 25.89
+	Hs
		1330927 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		E41L5_HUMAN (60-763): 1.14e-151: 465: 25.89
+	Hs
		925637 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		E41L5_HUMAN (60-763): 1.14e-151: 465: 25.89
+	Hs
		925608 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		E41LB_HUMAN (94-810): 5.41e-143: 448: 24.48
+	Hs
		564756 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		FARP1_HUMAN (75-603): 7.66e-132: 422: 31.37
+	Hs
		1331006 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		FARP1_HUMAN (75-603): 7.66e-132: 422: 31.37
+	Hs
		925760 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FARP1_HUMAN (75-603): 7.66e-132: 422: 31.37
+	Hs
		564429 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		719617 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		719441 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		719433 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MERL_HUMAN (87-655): 2.08e-128: 400: 22.05
+	Hs
		547002 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		EZRI_HUMAN (94-672): 1.1e-123: 387: 22.83
+	Hs
		719697 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RADI_HUMAN (94-672): 2.79e-119: 376: 21.44
+	Hs
		564749 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		E41L3_HUMAN (458-875): 1.5e-50: 195: 29.79
+	Hs
		1330999 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		E41L3_HUMAN (458-875): 1.5e-50: 195: 29.79
+	Hs
		925748 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		E41L3_HUMAN (458-875): 1.5e-50: 195: 29.79