HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PAK6 (Q9NQU5)
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Gene: PAK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	32707033, 31980649, 11773441, 20936779, unassigned2173
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 681
+	Hs
		1330933 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAK6_HUMAN (1-681): 0: 641: 100.00
+	Hs
		1330966 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAK5_HUMAN (1-676): 1.65e-174: 516: 44.51
+	Hs
		330841 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		331085 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330967 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		564425 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		AKT2_HUMAN (285-680): 9.96e-139: 416: 20.99
+	Hs
		681775 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AKT1_HUMAN (349-680): 1.47e-131: 398: 23.10
+	Hs
		568794 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Ce
		975572 RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97		PK1_CAEEL (161-680): 9.16e-127: 389: 33.58
+	Hs
		568619 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Hs
		564505 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Hs
		1026226 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Mm
		103566 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		G5E884_MOUSE (3-205): 2.63e-39: 154: 17.16
+	Hs
		564507 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63
+	Mm
		292040 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		PAK1_MOUSE (3-205): 7.18e-39: 153: 16.67
+	Hs
		925244 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Hs
		277619 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAK3_HUMAN (3-215): 8.38e-34: 138: 14.78
+	Hs
		1026945 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63
+	Hs
		277602 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PAK3_HUMAN (3-215): 8.38e-34: 138: 14.78
+	Mm
		925809 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		PAK2_MOUSE (9-162): 9.08e-34: 137: 19.26