HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: DIAP3 (Q9NSV4)
Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)
Gene: DIAPH3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	31871319, 15085137
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007229 - integrin-mediated signaling pathway GO:0030036 - actin cytoskeleton organization GO:0030225 - macrophage differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1193
+	Hs
		564704 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DIAP3_HUMAN (1-1193): 0: 1085: 100.00
+	Hs
		1330940 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DIAP3_HUMAN (1-1193): 0: 1085: 100.00
+	Hs
		925658 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DIAP3_HUMAN (1-1193): 0: 1085: 100.00
+	Hs
		564754 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		1331005 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		925759 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		925531 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FMNL2_HUMAN (112-1089): 0: 653: 21.45
+	Dd
		710114 RAC1A_DICDI (1-191): 6.92e-83: 245: 65.46		FORH_DICDI (91-1079): 0: 586: 21.75
+	Hs
		243091 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		237586 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DIAP1_HUMAN (20-635): 3.9e-134: 442: 37.97
+	Hs
		237577 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DIAP1_HUMAN (20-635): 3.9e-134: 442: 37.97
+	Hs
		243112 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		243100 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		243096 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		925315 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		INF2_HUMAN (612-1179): 3.52e-123: 412: 22.30
+	Hs
		925768 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FHOD1_HUMAN (130-1175): 1.1e-113: 384: 15.79
+	Hs
		925673 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FMN2_HUMAN (595-1059): 8.72e-101: 354: 24.08
+	Hs
		314890 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78
+	Hs
		314858 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78
+	Hs
		314853 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78