HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 800
+	Hs
		925212 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		893917 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		564442 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		925309 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		M3K11_HUMAN (12-331): 1.29e-112: 364: 37.01
+	Hs
		894058 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		M3K11_HUMAN (12-331): 1.29e-112: 364: 37.01
+	Hs
		951023 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		M3K11_HUMAN (12-331): 1.29e-112: 364: 37.01
+	Hs
		789092 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		789055 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Dm
		776899 RAC1_DROME (1-191): 1.02e-81: 242: 69.27		M3KSL_DROME (9-326): 1.33e-107: 357: 35.94
+	Dm
		776934 CDC42_DROME (1-191): 1.44e-80: 239: 92.67		M3KSL_DROME (9-326): 1.33e-107: 357: 35.94
+	Hs
		789051 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		433244 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		433475 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		433314 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		789109 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FRK_HUMAN (1-278): 1.25e-99: 319: 30.14
+	Hs
		433305 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		433322 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		433307 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		433239 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		YES_HUMAN (2-268): 9.65e-100: 321: 29.86
+	Hs
		199540 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		M3K13_HUMAN (10-295): 1.9e-51: 196: 38.41