HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: BORG2 (Q9UKI2)
Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein)
Gene: CDC42EP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	10490598, 9535835, 31478661, 31871319, 20936779
Identification Methods	pull down, two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031274 - positive regulation of pseudopodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 254
+	Hs
		564729 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG2_HUMAN (1-254): 4.45e-90: 268: 100.00
+	Hs
		564682 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		1330288 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		150121 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG1_HUMAN (1-253): 1.14e-54: 176: 40.39
+	Hs
		925610 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		894420 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		951333 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		900891 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		545611 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		BORG4_HUMAN (5-254): 1.83e-59: 193: 25.95
+	Hs
		564481 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		150124 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG1_HUMAN (1-253): 1.14e-54: 176: 40.39
+	Hs
		960657 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		925198 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		893907 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		950927 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		900382 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		545325 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		436256 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		892320 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		BORG5_HUMAN (12-252): 2.32e-48: 166: 24.49
+	Hs
		894139 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG3_HUMAN (5-62): 4.23e-12: 64: 44.83