HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PKHG1 (Q9ULL1)
Pleckstrin homology domain-containing family G member 1
Gene: PLEKHG1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1385
+	Hs
		564737 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PKHG1_HUMAN (1-1385): 0: 1725: 100.00
+	Hs
		548678 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		VAV_HUMAN (14-741): 4.36e-117: 389: 15.54
+	Hs
		855782 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		VAV2_HUMAN (13-704): 4.43e-114: 381: 16.85
+	Hs
		50555 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		PKHG3_HUMAN (9-1193): 8.56e-102: 355: 30.27
+	Hs
		564524 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ARHG7_HUMAN (11-624): 4.82e-102: 346: 20.16
+	Hs
		50617 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		PKHG3_HUMAN (9-1193): 8.56e-102: 355: 30.27
+	Hs
		50580 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PKHG3_HUMAN (9-1193): 8.56e-102: 355: 30.27
+	Hs
		1049733 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ARHG7_HUMAN (11-624): 4.82e-102: 346: 20.16
+	Hs
		564535 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ARHG6_HUMAN (4-676): 3.61e-96: 329: 18.71
+	Hs
		925271 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARHG7_HUMAN (11-624): 4.82e-102: 346: 20.16
+	Hs
		1066050 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ARHG6_HUMAN (4-676): 3.61e-96: 329: 18.71
+	Hs
		925289 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARHG6_HUMAN (4-676): 3.61e-96: 329: 18.71
+	Gg
		1141019 Q6LC82_CHICK (1-191): 1.75e-84: 249: 70.31		ARHG6_CHICK (7-670): 5.67e-95: 325: 18.73
+	Hs
		166482 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MCF2L_HUMAN (27-598): 1.62e-88: 315: 20.49
+	Hs
		564502 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		TIAM1_HUMAN (11-585): 3.66e-79: 290: 20.32
+	Hs
		500934 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MCF2_HUMAN (44-499): 4.59e-84: 298: 23.00
+	Hs
		1022453 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		TIAM1_HUMAN (11-585): 3.66e-79: 290: 20.32
+	Hs
		925241 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TIAM1_HUMAN (11-585): 3.66e-79: 290: 20.32
+	Hs
		224711 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		KALRN_HUMAN (63-688): 3.15e-70: 263: 19.94
+	Hs
		279854 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TRIO_HUMAN (102-752): 4.25e-67: 253: 19.36