HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032991 - protein-containing complex GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 522
+	Hs
		925762 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		436589 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		925782 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		893946 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		893954 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Dm
		776927 RAC1_DROME (1-191): 1.02e-81: 242: 69.27		Q9W3I9_DROME (44-500): 2.42e-60: 208: 23.80
+	Dm
		776928 RAC1_DROME (1-191): 1.02e-81: 242: 69.27		Q9XYQ9_DROME (44-500): 1.02e-58: 203: 23.36
+	Hs
		301708 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		436461 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		TRI47_HUMAN (67-316): 1.02e-36: 145: 17.84
+	Hs
		564578 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		925367 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		894143 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		900602 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		545451 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		436419 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84