HitPredict

Interactor 1: RAB8A (P61006)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Interactor 2: MILK2 (Q8IY33)
MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)
Gene: MICALL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.818

Property	Details
Experiments	36307841, 26824392, 29125462
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~bMERB_dom
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031267 - small GTPase binding GO:0032456 - endocytic recycling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 207 Hs			1 904
+	Hs
		845867 RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17		MILK2_HUMAN (1-904): 9.07e-111: 363: 100.00
+	Hs
		1222038 RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61		MILK2_HUMAN (1-904): 9.07e-111: 363: 100.00
+	Hs
		894773 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		EHBP1_HUMAN (3-890): 4.36e-79: 281: 16.01
+	Mm
		292526 RAB10_MOUSE (3-181): 4.07e-93: 272: 75.98		ACTN3_MOUSE (2-219): 6.55e-70: 251: 30.28
+	Hs
		914223 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		EHBP1_HUMAN (3-890): 4.36e-79: 281: 16.01
+	Hs
		895513 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		MILK1_HUMAN (2-885): 2.52e-61: 225: 29.81
+	Mm
		1112011 RAB13_MOUSE (1-206): 2.37e-89: 262: 62.62		MILK2_MOUSE (1-888): 7.2e-61: 226: 40.66
+	Hs
		845869 RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17		MILK1_HUMAN (2-885): 2.52e-61: 225: 29.81
+	Hs
		895525 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		MICA1_HUMAN (372-865): 2.36e-55: 210: 18.15
+	Hs
		894767 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MILK1_HUMAN (2-885): 2.52e-61: 225: 29.81
+	Hs
		1232324 RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61		MILK1_HUMAN (2-885): 2.52e-61: 225: 29.81
+	Hs
		914014 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		SPTB2_HUMAN (2-219): 3.33e-61: 229: 30.28
+	Hs
		918915 RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41		MICA1_HUMAN (372-865): 2.36e-55: 210: 18.15
+	Hs
		914208 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		MILK1_HUMAN (2-885): 2.52e-61: 225: 29.81
+	Hs
		1255762 RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96		MICA1_HUMAN (372-865): 2.36e-55: 210: 18.15
+	Hs
		894779 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MICA1_HUMAN (372-865): 2.36e-55: 210: 18.15
+	Hs
		895507 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		MICA3_HUMAN (120-749): 1.02e-11: 71.5: 9.15
+	Hs
		894754 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MICA3_HUMAN (120-749): 1.02e-11: 71.5: 9.15
+	Hs
		1186079 RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61		MICA3_HUMAN (120-749): 1.02e-11: 71.5: 9.15
+	Hs
		914166 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		MICA3_HUMAN (120-749): 1.02e-11: 71.5: 9.15