HitPredict

Interactor 1: RAB8A (P61006)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.743

Property	Details
Experiments	11137014, 20634958, 20161783, 20085643, 23357852, 20388642, 22854040
Identification Methods	two hybrid, pull down, affinity chromatography technology, bimolecular fluorescence complementation, confocal microscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005829 - cytosol GO:0006914 - autophagy GO:0007030 - Golgi organization GO:0055038 - recycling endosome membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 207 Hs			1 577
+	Hs
		895537 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1079953 RB11B_HUMAN (4-204): 1.1e-88: 261: 41.63		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287377 RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		914277 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1079980 RB11B_HUMAN (4-204): 1.1e-88: 261: 41.63		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Mm
		914516 RB11A_MOUSE (4-204): 5.02e-81: 242: 41.06		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Hs
		894836 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		914503 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		894733 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		914091 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		148600 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		148551 RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		148636 RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		149274 RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		894813 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		914103 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		914383 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		254466 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22