HitPredict

Interactor 1: RAB5B (P61020)
Ras-related protein Rab-5B (EC 3.6.5.2)
Gene: RAB5B

Interactor 2: RIN3 (Q8TB24)
Ras and Rab interactor 3 (Ras interaction/interference protein 3)
Gene: RIN3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	12972505
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~VPS9
Common GO terms	GO:0005769 - early endosome GO:0006897 - endocytosis GO:0030139 - endocytic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 985
+	Hs
		1137131 Q5U0I6_HUMAN (10-213): 8.59e-91: 266: 39.51		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		918912 RAB1A_HUMAN (10-213): 8.59e-91: 266: 39.51		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		592390 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		72912 B4DMN1_HUMAN (7-215): 4.05e-87: 259: 38.53		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		844638 RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	At
		1339601 RAF2B_ARATH (22-214): 5.75e-75: 226: 60.83		VPS9A_ARATH (608-957): 3.11e-66: 233: 12.71
+	Hs
		592565 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Ce
		954788 P91857_CAEEL (1-213): 3.35e-100: 290: 75.35		Q8I100_CAEEL (564-862): 2.05e-40: 159: 18.09
+	Hs
		844787 RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Hs
		914438 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Hs
		592583 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		MACF1_HUMAN (588-905): 2.12e-44: 178: 15.92
+	Ce
		954790 P91857_CAEEL (1-213): 3.35e-100: 290: 75.35		RME6_CAEEL (632-840): 2.29e-35: 148: 16.27
+	Dm
		1358752 RAB5_DROME (3-213): 2.42e-97: 283: 72.51		Q9W0H9_DROME (672-876): 1.21e-35: 147: 15.05
+	Dm
		1228833 RAB5_DROME (3-213): 2.42e-97: 283: 72.51		SPRI_DROME (34-706): 2.23e-33: 142: 16.72
+	Hs
		895371 RAB5B_HUMAN (1-215): 4.67e-90: 265: 100.00		RIN2_HUMAN (28-376): 3.27e-39: 159: 28.49
+	Hs
		592407 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RIN2_HUMAN (28-376): 3.27e-39: 159: 28.49
+	Hs
		1355935 RB22A_HUMAN (20-213): 7.44e-62: 192: 47.94		RABX5_HUMAN (548-876): 7.79e-51: 189: 15.32
+	Sc
		731194 VPS21_YEAST (16-188): 9.25e-64: 198: 59.55		VPS9_YEAST (565-923): 3.91e-45: 171: 15.82
+	Hs
		895350 RAB5B_HUMAN (1-215): 4.67e-90: 265: 100.00		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		592240 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32