HitPredict

Interactor 1: RAB5B (P61020)
Ras-related protein Rab-5B (EC 3.6.5.2)
Gene: RAB5B

Interactor 2: RIN2 (Q8WYP3)
Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)
Gene: RIN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	11733506
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RA~Ras, Ras~VPS9
Common GO terms	GO:0006897 - endocytosis GO:0030139 - endocytic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 895
+	Hs
		592407 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RIN2_HUMAN (1-895): 0: 1026: 100.00
+	Hs
		1137131 Q5U0I6_HUMAN (10-213): 8.59e-91: 266: 39.51		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		918912 RAB1A_HUMAN (10-213): 8.59e-91: 266: 39.51		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		895368 RAB5B_HUMAN (1-215): 4.67e-90: 265: 100.00		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		592390 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		72912 B4DMN1_HUMAN (7-215): 4.05e-87: 259: 38.53		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		844638 RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Ce
		954790 P91857_CAEEL (1-213): 3.35e-100: 290: 75.35		RME6_CAEEL (189-751): 5.52e-91: 313: 12.21
+	Dm
		1358752 RAB5_DROME (3-213): 2.42e-97: 283: 72.51		Q9W0H9_DROME (350-786): 1.66e-82: 281: 14.77
+	Hs
		592565 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RABX5_HUMAN (393-781): 9.51e-82: 274: 14.50
+	Dm
		1228833 RAB5_DROME (3-213): 2.42e-97: 283: 72.51		SPRI_DROME (69-471): 6.47e-69: 252: 18.92
+	Hs
		844787 RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26		RABX5_HUMAN (393-781): 9.51e-82: 274: 14.50
+	Hs
		914438 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		RABX5_HUMAN (393-781): 9.51e-82: 274: 14.50
+	Ce
		954788 P91857_CAEEL (1-213): 3.35e-100: 290: 75.35		Q8I100_CAEEL (434-770): 7.08e-57: 206: 16.13
+	Hs
		895350 RAB5B_HUMAN (1-215): 4.67e-90: 265: 100.00		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Hs
		592240 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Hs
		433251 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		433295 RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		433312 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		522882 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79