HitPredict

Interactor 1: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	28514442, 32296183, 33961781, 26186194, 23602568, 7809159, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, validated two hybrid, two hybrid array, two hybrid prey pooling approach, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 79 Hs			1 305
+	Hs
		706796 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Hs
		625283 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		625164 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		414843 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	At
		188136 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKA1_ARATH (1-293): 1.36e-137: 392: 68.03
+	Hs
		414778 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	At
		621728 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CDKA1_ARATH (1-293): 1.36e-137: 392: 68.03
+	Ce
		712291 CKS1_CAEEL (4-78): 6.93e-42: 133: 65.33		CDK1_CAEEL (1-294): 4.01e-130: 375: 62.25
+	Hs
		895414 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Dm
		618415 Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83		CDK1_DROME (1-288): 2.07e-133: 381: 65.40
+	Hs
		706797 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	At
		188147 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB12_ARATH (1-292): 1.59e-131: 377: 56.77
+	At
		1103378 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CKB12_ARATH (1-292): 1.59e-131: 377: 56.77
+	At
		188156 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB21_ARATH (1-295): 7.48e-130: 373: 50.99
+	At
		188157 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB22_ARATH (1-295): 1.82e-129: 372: 51.97
+	Dm
		618471 Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83		CDK2_DROME (1-301): 6.29e-129: 371: 60.47
+	At
		1227962 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CKB21_ARATH (1-295): 7.48e-130: 373: 50.99
+	At
		188163 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKD2_ARATH (1-302): 9.62e-128: 369: 48.01
+	At
		188137 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB11_ARATH (1-292): 3.44e-126: 364: 56.17
+	At
		639376 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CKB11_ARATH (1-292): 3.44e-126: 364: 56.17