HitPredict

Interactor 1: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005654 - nucleoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 79 Hs			1 292
+	Hs
		625283 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		625164 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		895413 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		706796 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		706797 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414843 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		414778 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	At
		188136 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	At
		621728 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	Dm
		618415 Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83		CDK1_DROME (1-287): 4.06e-130: 373: 56.40
+	At
		188163 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKD2_ARATH (1-292): 2.99e-129: 372: 46.58
+	At
		188168 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKD3_ARATH (2-292): 2.44e-126: 366: 47.77
+	Dm
		618471 Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83		CDK2_DROME (1-289): 8.92e-127: 365: 49.48
+	Ce
		712291 CKS1_CAEEL (4-78): 6.93e-42: 133: 65.33		CDK1_CAEEL (1-288): 7.03e-122: 353: 52.53
+	At
		188157 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB22_ARATH (1-291): 1.1e-123: 357: 49.83
+	At
		188147 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB12_ARATH (1-289): 1.61e-123: 356: 50.97
+	At
		1103378 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CKB12_ARATH (1-289): 1.61e-123: 356: 50.97
+	At
		188156 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB21_ARATH (1-290): 1.28e-121: 352: 48.00
+	At
		188137 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98
+	At
		639376 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98