HitPredict

Interactor 1: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Interactor 2: RNF38 (Q9H0F5)
E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38)
Gene: RNF38

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 515
+	Hs
		1327690 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RNF38_HUMAN (1-515): 5.32e-114: 348: 100.00
+	Hs
		1169203 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RN111_HUMAN (2-508): 6.5e-50: 186: 17.74
+	Hs
		196372 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62
+	Hs
		196294 UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28		PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62
+	At
		96605 UBC9_ARATH (1-147): 6.25e-82: 239: 79.59		F4IQ07_ARATH (11-510): 2.09e-51: 186: 13.16
+	At
		715138 UBC9_ARATH (1-147): 6.25e-82: 239: 79.59		Q8VYL4_ARATH (11-510): 3.76e-46: 171: 13.16
+	Hs
		1313520 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RN126_HUMAN (253-514): 1e-42: 156: 19.29
+	Hs
		1377467 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RN115_HUMAN (260-515): 7.52e-39: 145: 17.36
+	At
		715139 UBC9_ARATH (1-147): 6.25e-82: 239: 79.59		RHG1A_ARATH (57-505): 3.66e-35: 141: 17.59
+	At
		715158 UBC11_ARATH (1-147): 3.57e-82: 239: 78.91		RHG1A_ARATH (57-505): 3.66e-35: 141: 17.59
+	Hs
		1346940 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RNF12_HUMAN (13-508): 1.16e-32: 133: 16.41
+	At
		715137 UBC9_ARATH (1-147): 6.25e-82: 239: 79.59		RNG1L_ARATH (312-515): 1.71e-34: 134: 20.09
+	Hs
		1170316 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		ARK2C_HUMAN (158-510): 4e-31: 125: 19.95
+	Hs
		1242076 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		ZNRF1_HUMAN (290-501): 1.92e-31: 122: 15.25
+	Zm
		74334 B4FC97_MAIZE (1-147): 8.22e-83: 241: 78.91		B6U926_MAIZE (267-515): 7.12e-30: 122: 16.36
+	Zm
		79637 B6SZE0_MAIZE (1-147): 1.06e-82: 241: 78.91		B6U926_MAIZE (267-515): 7.12e-30: 122: 16.36
+	At
		715128 UBC8_ARATH (1-147): 2.25e-82: 240: 79.59		CIP8_ARATH (264-515): 6.52e-30: 121: 14.89
+	Hs
		1356934 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RN150_HUMAN (429-510): 8.55e-27: 114: 32.93
+	Hs
		207572 UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84		RNF13_HUMAN (440-509): 6.48e-27: 114: 36.62
+	Hs
		207553 UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28		RNF13_HUMAN (440-509): 6.48e-27: 114: 36.62