HitPredict

Interactor 1: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28581483, 32494016
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 759
+	Hs
		849326 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		895791 UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043149 UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		895792 UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		849325 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		919724 UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1042304 UB2E2_HUMAN (5-173): 1.08e-73: 222: 28.66		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1042223 UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		851812 UB2E1_HUMAN (5-173): 1.45e-72: 218: 28.07		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		896074 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Dm
		1213851 UBC2M_DROME (1-182): 2.32e-74: 222: 75.28		Q8IP45_DROME (51-759): 0: 776: 36.20
+	Hs
		1041136 UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90		CUL1_HUMAN (59-759): 0: 745: 30.55
+	At
		1277342 RCE1_ARATH (1-182): 7.99e-72: 216: 60.33		CUL1_ARATH (57-759): 0: 744: 34.20
+	Hs
		896072 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		849324 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Dm
		639393 UBCD1_DROME (30-173): 5.31e-75: 223: 32.88		CUL1_DROME (59-759): 0: 709: 29.80
+	Dm
		1097207 UBC2M_DROME (1-182): 2.32e-74: 222: 75.28		CUL1_DROME (59-759): 0: 709: 29.80
+	Hs
		895790 UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		896073 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Sp
		804458 UBC4_SCHPO (30-173): 2.69e-74: 221: 34.93		CUL3_SCHPO (38-759): 0: 662: 32.15