HitPredict

Interactor 1: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Interactor 2: DCNL2 (Q6PH85)
DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
Gene: DCUN1D2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	23201271, 26906416, 28581483, 19617556
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045116 - protein neddylation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 259
+	Hs
		895881 UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		896181 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		1161495 UBE2F_HUMAN (12-164): 1.41e-33: 119: 39.51		DCNL2_HUMAN (1-259): 1.23e-132: 376: 100.00
+	Hs
		1281713 UBE2F_HUMAN (12-164): 1.41e-33: 119: 39.51		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		896168 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		DCNL4_HUMAN (42-250): 1.37e-90: 271: 34.45
+	Hs
		896205 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		DCNL5_HUMAN (55-248): 4.09e-86: 258: 34.54
+	Hs
		896143 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		DCNL3_HUMAN (53-246): 4.59e-84: 254: 45.77
+	Sc
		854628 UBC12_YEAST (1-173): 4.43e-45: 148: 43.02		DCN1_YEAST (3-250): 1.24e-83: 252: 23.19
+	Hs
		1281715 UBE2F_HUMAN (12-164): 1.41e-33: 119: 39.51		DCNL5_HUMAN (55-248): 4.09e-86: 258: 34.54
+	Hs
		1218598 UBE2F_HUMAN (12-164): 1.41e-33: 119: 39.51		DCNL3_HUMAN (53-246): 4.59e-84: 254: 45.77