HitPredict

Interactor 1: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Interactor 2: KLH13 (Q9P2N7)
Kelch-like protein 13 (BTB and kelch domain-containing protein 2)
Gene: KLHL13

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28581483
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 655
+	Hs
		849471 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KLH13_HUMAN (1-655): 0: 599: 100.00
+	Hs
		849470 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KLHL9_HUMAN (43-655): 0: 548: 92.82
+	Hs
		896241 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLHL9_HUMAN (43-655): 0: 548: 92.82
+	Hs
		896118 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH22_HUMAN (38-651): 1.39e-136: 415: 32.54
+	Hs
		896269 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH20_HUMAN (472-652): 2.43e-39: 155: 24.73
+	Hs
		299511 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH18_HUMAN (469-648): 2.17e-38: 151: 23.08
+	Hs
		849329 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KEAP1_HUMAN (475-647): 4.49e-32: 133: 24.28
+	Hs
		895941 UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51		KLHL3_HUMAN (484-653): 8.81e-33: 135: 22.35
+	Hs
		307160 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KLHL2_HUMAN (488-653): 2.74e-29: 124: 21.69
+	Hs
		828997 UBE2A_HUMAN (26-172): 2.67e-69: 208: 28.19		KEAP1_HUMAN (475-647): 4.49e-32: 133: 24.28
+	Hs
		896130 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH24_HUMAN (426-650): 1.38e-27: 119: 20.26
+	Hs
		896119 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH26_HUMAN (420-651): 4.86e-20: 96.5: 15.94
+	Hs
		896117 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH12_HUMAN (522-650): 3e-19: 93.8: 24.24
+	Hs
		135913 UBE2C_HUMAN (10-155): 3e-22: 90.1: 34.46		KLHL2_HUMAN (488-653): 2.74e-29: 124: 21.69
+	Hs
		307184 Q5TZN3_HUMAN (10-155): 3e-22: 90.1: 34.46		KLHL2_HUMAN (488-653): 2.74e-29: 124: 21.69