HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RL40 (P62987)
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Gene: UBA52

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 128
+	Ce
		829760 Q9TZ69_CAEEL (1-199): 1.29e-81: 242: 52.26		RL40_CAEEL (1-128): 1.35e-53: 165: 92.97
+	Hs
		895774 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		RL40_HUMAN (1-128): 1.05e-56: 174: 100.00
+	Hs
		896295 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70
+	Xl
		919927 UB2D2_XENLA (4-154): 7.76e-75: 223: 41.06		Q7SY79_XENLA (1-77): 3.33e-41: 145: 98.70
+	Dm
		639414 UBCD1_DROME (4-154): 2.12e-74: 222: 41.72		Q9W418_DROME (1-77): 1.45e-41: 145: 98.70
+	Hs
		474976 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		UBB_HUMAN (1-76): 1.52e-33: 118: 100.00
+	Hs
		895773 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70
+	Hs
		475249 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		UBB_HUMAN (1-76): 1.52e-33: 118: 100.00
+	At
		1092025 UBC27_ARATH (7-199): 8.4e-75: 225: 48.19		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	At
		1091932 UBC28_ARATH (4-155): 6.45e-75: 224: 41.45		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	Hs
		474984 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UBB_HUMAN (1-76): 1.52e-33: 118: 100.00
+	At
		715116 UBC8_ARATH (4-155): 1.43e-74: 222: 41.45		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	At
		715157 UBC11_ARATH (4-155): 3.76e-74: 222: 42.11		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	At
		715132 UBC9_ARATH (4-155): 4.47e-74: 221: 42.11		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	At
		715147 UBC10_ARATH (4-155): 6.01e-74: 221: 41.45		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	Hs
		70479 UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40		B2RDW1_HUMAN (1-77): 2.11e-38: 128: 98.70
+	Hs
		1137415 UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40		Q5U5U6_HUMAN (1-76): 1.52e-33: 118: 100.00
+	Hs
		475124 UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40		UBB_HUMAN (1-76): 1.52e-33: 118: 100.00
+	At
		639385 UBC1_ARATH (1-151): 3.62e-67: 204: 32.45		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59
+	At
		790155 UBC2_ARATH (1-151): 3.14e-67: 204: 31.79		UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59