HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	15723079, 21098080, 29773808, 18691969, 21139563
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UBA~UQ_con, UQ_con~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 200 Hs			1 158
+	Hs
		1377464 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42
+	Hs
		849296 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Zm
		74428 B4FCQ9_MAIZE (4-155): 5.41e-75: 224: 40.79		B4FCQ9_MAIZE (4-157): 6.06e-75: 221: 35.71
+	Zm
		79635 B6SZE0_MAIZE (4-155): 1.13e-74: 223: 41.45		B6SZE0_MAIZE (4-157): 1.96e-74: 220: 35.71
+	Hs
		919702 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		849299 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		895960 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Zm
		41174 A0A1D6NGW9_MAIZE (4-150): 4.93e-73: 222: 42.86		A0A1D6NGW9_MAIZE (4-153): 5.96e-72: 217: 35.33
+	Hs
		895770 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		895766 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Sc
		549782 UBC4_YEAST (1-153): 6.39e-73: 218: 41.83		UBC4_YEAST (1-156): 1.22e-72: 216: 35.90
+	Sc
		549783 UBC4_YEAST (1-153): 6.39e-73: 218: 41.83		UBC5_YEAST (1-156): 5.84e-72: 214: 35.26
+	Zm
		8399 A0A1D6ENM7_MAIZE (2-155): 1.94e-75: 226: 40.26		A0A1D6LKH6_MAIZE (1-154): 6.82e-67: 202: 38.31
+	Dm
		854584 UBCD4_DROME (1-199): 3.1e-73: 221: 68.34		Q7KNM2_DROME (1-158): 1.41e-66: 201: 85.44
+	Hs
		1297356 UB2E2_HUMAN (3-153): 3.57e-68: 208: 40.40		UB2E2_HUMAN (3-156): 7.29e-69: 208: 33.77