HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: DTX3 (Q8N9I9)
Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)
Gene: DTX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	25416956, 32296183, 19549727, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 347
+	Hs
		1238409 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		DTX3_HUMAN (1-347): 3.76e-169: 476: 100.00
+	Hs
		849372 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		DTX3_HUMAN (1-347): 3.76e-169: 476: 100.00
+	Hs
		919787 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		DTX3_HUMAN (1-347): 3.76e-169: 476: 100.00
+	Hs
		896339 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		DTX3L_HUMAN (98-344): 1.73e-105: 327: 44.13
+	Hs
		1254722 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		DTX3L_HUMAN (98-344): 1.73e-105: 327: 44.13
+	Hs
		849380 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		DTX3L_HUMAN (98-344): 1.73e-105: 327: 44.13
+	Hs
		919797 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		DTX3L_HUMAN (98-344): 1.73e-105: 327: 44.13
+	Hs
		1200380 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		DTX2_HUMAN (89-347): 1.07e-97: 303: 31.40
+	Hs
		849356 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		DTX2_HUMAN (89-347): 1.07e-97: 303: 31.40
+	Hs
		919770 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		DTX2_HUMAN (89-347): 1.07e-97: 303: 31.40
+	Hs
		1205017 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		DTX1_HUMAN (73-346): 1.28e-92: 290: 27.69
+	Hs
		849361 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		DTX1_HUMAN (73-346): 1.28e-92: 290: 27.69
+	Hs
		919774 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		DTX1_HUMAN (73-346): 1.28e-92: 290: 27.69
+	Zm
		39810 B4FCQ9_MAIZE (4-155): 5.41e-75: 224: 40.79		A0A1D6N2L7_MAIZE (66-203): 2.48e-41: 146: 26.57
+	Hs
		896395 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		AMFR_HUMAN (152-213): 5.25e-17: 84.1: 27.42
+	Hs
		1345306 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TOPRS_HUMAN (130-206): 1.2e-17: 86.4: 23.38
+	Hs
		849457 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TOPRS_HUMAN (130-206): 1.2e-17: 86.4: 23.38
+	Hs
		1356614 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		AMFR_HUMAN (152-213): 5.25e-17: 84.1: 27.42
+	Hs
		849484 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		AMFR_HUMAN (152-213): 5.25e-17: 84.1: 27.42
+	Hs
		919766 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		SYVN1_HUMAN (126-204): 6.26e-17: 83.7: 24.05