HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: BIRC7 (Q96CA5)
Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]
Gene: BIRC7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	19549727, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 298
+	Hs
		849400 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BIRC7_HUMAN (1-298): 4.39e-104: 307: 100.00
+	Hs
		849456 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BIRC6_HUMAN (54-252): 6.52e-36: 138: 21.10
+	Hs
		1264347 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		MYLIP_HUMAN (152-297): 3.79e-26: 108: 22.45
+	Hs
		849386 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		MYLIP_HUMAN (152-297): 3.79e-26: 108: 22.45
+	Hs
		896319 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		Q6PIA0_HUMAN (1-91): 4.23e-17: 80.4: 17.20
+	Hs
		896357 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		BIRC8_HUMAN (1-96): 5.33e-17: 80.4: 18.18
+	Hs
		849396 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		MIB2_HUMAN (236-297): 7.71e-23: 100: 38.71
+	Hs
		282379 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		NEUL1_HUMAN (167-298): 1.14e-22: 99.6: 22.46
+	Hs
		849321 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Hs
		1206094 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		MIB1_HUMAN (206-296): 7.37e-20: 91.6: 25.28
+	Hs
		849363 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		MIB1_HUMAN (206-296): 7.37e-20: 91.6: 25.28
+	Hs
		919721 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Hs
		919776 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		MIB1_HUMAN (206-296): 7.37e-20: 91.6: 25.28
+	Hs
		849322 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Hs
		919722 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Hs
		1298970 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		BIRC8_HUMAN (1-96): 5.33e-17: 80.4: 18.18
+	Hs
		849413 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BIRC8_HUMAN (1-96): 5.33e-17: 80.4: 18.18
+	Hs
		849308 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Hs
		957802 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Hs
		919707 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19