HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.768

Property	Details
Experiments	32296183, 19549727
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000209 - protein polyubiquitination GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 232
+	Hs
		1290204 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN125_HUMAN (1-232): 1.03e-55: 179: 100.00
+	Hs
		896402 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN114_HUMAN (9-225): 2.79e-44: 150: 29.26
+	Hs
		896346 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN166_HUMAN (1-224): 1.46e-42: 145: 30.83
+	Hs
		896381 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI39_HUMAN (28-229): 3.66e-38: 140: 16.90
+	Hs
		896369 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		896348 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI43_HUMAN (24-229): 1.32e-35: 132: 15.09
+	Hs
		896371 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM2_HUMAN (17-227): 1.61e-34: 131: 13.97
+	Hs
		896370 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM5_HUMAN (24-229): 2.94e-33: 126: 15.81
+	Hs
		1283434 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN166_HUMAN (1-224): 1.46e-42: 145: 30.83
+	Hs
		536773 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		896344 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN138_HUMAN (21-222): 4.17e-34: 124: 26.25
+	Hs
		896398 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI35_HUMAN (18-229): 2.74e-32: 124: 12.67
+	Hs
		1318532 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		1285831 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI43_HUMAN (24-229): 1.32e-35: 132: 15.09
+	Hs
		896366 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI34_HUMAN (31-167): 2.14e-26: 108: 20.14
+	Hs
		537142 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		1261313 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN138_HUMAN (21-222): 4.17e-34: 124: 26.25
+	Hs
		1252560 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17
+	Hs
		896376 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18
+	Xl
		1140146 Q8AVM8_XENLA (1-200): 1.98e-82: 244: 97.00		Q5XGX4_XENLA (1-84): 1.67e-10: 60.1: 27.91