HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: APC11 (Q9NYG5)
Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)
Gene: ANAPC11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	17632060, 24930963, 18662541
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0034450 - ubiquitin-ubiquitin ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 84
+	Hs
		849463 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		849303 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		895979 UB2D1_MOUSE (4-154): 1.87e-75: 225: 39.74		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Hs
		921482 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Hs
		919882 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		919703 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		919923 UB2D2_MOUSE (4-154): 7.76e-75: 223: 41.06		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Ce
		715111 UBC2_CAEEL (4-154): 9.25e-75: 223: 41.72		RBX1_CAEEL (2-84): 2.72e-28: 99.8: 37.50
+	Hs
		895932 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		895771 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		895973 UB2D3_MOUSE (4-154): 1.49e-73: 220: 39.74		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Ce
		715108 UBC2_CAEEL (4-154): 9.25e-75: 223: 41.72		APC11_CAEEL (1-84): 1.57e-26: 95.9: 45.98
+	Sp
		804461 UBC4_SCHPO (4-153): 2.34e-73: 219: 42.00		APC11_SCHPO (1-83): 8.94e-28: 97.8: 51.19
+	Sc
		549843 UBC4_YEAST (1-153): 6.39e-73: 218: 41.83		RBX1_YEAST (2-84): 3.85e-26: 94.4: 34.09
+	Hs
		1354003 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		849472 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		919890 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		895936 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		296887 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81
+	Hs
		296893 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81