HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 1024
+	Hs
		849478 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		125301 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		896355 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		896359 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		NED4L_HUMAN (652-1023): 2.49e-164: 510: 28.13
+	Hs
		849311 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		919710 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		849444 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125262 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125808 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125335 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1294888 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		808052 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		849411 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		849416 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		NED4L_HUMAN (652-1023): 2.49e-164: 510: 28.13
+	Hs
		808078 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		896380 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Hs
		849351 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94
+	Hs
		849451 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22
+	Hs
		849452 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Hs
		849333 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88