HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: TRIM2 (Q9C040)
Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)
Gene: TRIM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36481767
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 744
+	Hs
		1318738 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM2_HUMAN (1-744): 0: 649: 100.00
+	Hs
		262201 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM3_HUMAN (1-744): 0: 607: 65.86
+	Hs
		262161 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRIM3_HUMAN (1-744): 0: 607: 65.86
+	Hs
		1336390 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI39_HUMAN (14-490): 4.43e-91: 296: 15.96
+	Hs
		537142 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI27_HUMAN (8-509): 4.56e-84: 277: 13.11
+	Hs
		536760 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI27_HUMAN (8-509): 4.56e-84: 277: 13.11
+	Hs
		1318719 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM5_HUMAN (10-497): 3.15e-81: 269: 14.26
+	Hs
		1333889 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI45_HUMAN (23-503): 9.71e-79: 265: 22.51
+	Hs
		135045 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI38_HUMAN (8-484): 8.26e-78: 259: 14.69
+	Hs
		135012 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI38_HUMAN (8-484): 8.26e-78: 259: 14.69
+	Hs
		1204911 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI50_HUMAN (8-485): 1.62e-74: 251: 14.55
+	Hs
		1377469 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI17_HUMAN (8-490): 3.27e-74: 250: 13.12
+	Hs
		1354526 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI10_HUMAN (8-484): 1.33e-72: 246: 14.68
+	Hs
		170304 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TIF1A_HUMAN (22-327): 7.48e-64: 232: 18.25
+	Hs
		175730 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI18_HUMAN (15-449): 2.83e-65: 230: 16.51
+	Hs
		175653 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI18_HUMAN (15-449): 2.83e-65: 230: 16.51
+	Hs
		1317493 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI54_HUMAN (13-317): 1.92e-59: 206: 21.78
+	Mm
		895980 UB2D1_MOUSE (4-149): 3.22e-80: 235: 45.21		LIN41_MOUSE (597-742): 5.03e-18: 90.9: 28.40
+	Hs
		1313765 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI62_HUMAN (18-290): 8.77e-16: 82.8: 25.44
+	Hs
		734819 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI23_HUMAN (19-172): 3.16e-15: 81.3: 30.72