HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	19690564, 19549727, 28292929, 29537486, 31985874, 18615712, 15231748, 23751493
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 154
+	Hs
		1377465 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		849494 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		207572 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		207545 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RNF13_HUMAN (77-146): 1.55e-26: 104: 33.80
+	Hs
		1377467 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RN115_HUMAN (10-154): 2e-26: 102: 19.08
+	At
		715137 UBC9_ARATH (4-149): 7.83e-80: 234: 46.58		RNG1L_ARATH (15-153): 5.68e-27: 104: 23.61
+	Zm
		74334 B4FC97_MAIZE (4-149): 4.83e-81: 237: 46.58		B6U926_MAIZE (52-153): 2.57e-25: 101: 29.52
+	Hs
		1204871 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	Zm
		79637 B6SZE0_MAIZE (4-149): 7.83e-81: 236: 47.95		B6U926_MAIZE (52-153): 2.57e-25: 101: 29.52
+	Hs
		849497 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN115_HUMAN (10-154): 2e-26: 102: 19.08
+	Hs
		849359 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		GOLI_HUMAN (57-146): 1.98e-25: 101: 24.44
+	Hs
		849382 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1356934 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RN150_HUMAN (57-146): 3.61e-24: 98.4: 26.67
+	Hs
		849491 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RNF6_HUMAN (1-149): 3.51e-24: 99.2: 20.83
+	Hs
		849485 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN150_HUMAN (57-146): 3.61e-24: 98.4: 26.67
+	At
		715158 UBC11_ARATH (4-149): 5.1e-80: 234: 46.58		RHG1A_ARATH (13-141): 1.35e-23: 97.6: 14.93
+	Hs
		1346940 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		849459 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		1332598 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RN167_HUMAN (77-143): 4.96e-21: 89.1: 36.77
+	Hs
		849446 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN167_HUMAN (77-143): 4.96e-21: 89.1: 36.77