HitPredict

Interactor 1: RAB14 (P61106)
Ras-related protein Rab-14 (EC 3.6.5.2)
Gene: RAB14

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	19702578
Identification Methods	far western blotting, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005802 - trans-Golgi network GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0055038 - recycling endosome membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 577
+	Hs
		914277 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1079953 RB11B_HUMAN (1-215): 1.84e-84: 251: 44.65		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287377 RAB1B_HUMAN (4-215): 8.23e-84: 249: 40.57		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Mm
		914516 RB11A_MOUSE (1-213): 8.5e-86: 254: 45.54		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Hs
		914503 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1079980 RB11B_HUMAN (1-215): 1.84e-84: 251: 44.65		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		895077 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		914091 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		895213 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		895105 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		254463 RAB2A_HUMAN (8-195): 6.73e-96: 280: 62.77		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22
+	Hs
		148636 RAB1A_HUMAN (1-215): 1.44e-87: 258: 42.33		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		914103 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		914383 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		149274 RAB1B_HUMAN (4-215): 8.23e-84: 249: 40.57		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		254466 RB11A_HUMAN (1-213): 8.5e-86: 254: 45.54		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22