HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Metallophos
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 327
+	Hs
		737679 ARP3_HUMAN (1-418): 0: 588: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		891663 ACTB_HUMAN (1-414): 0: 539: 35.66		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		906403 ACTG_HUMAN (1-414): 0: 538: 35.42		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		906407 ACTS_HUMAN (3-414): 0: 528: 35.59		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		906406 ACTC_HUMAN (3-414): 0: 527: 35.59		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		891662 ACTB_HUMAN (1-414): 0: 539: 35.66		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Mm
		906230 ACTG_MOUSE (1-414): 0: 538: 35.42		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		737677 ACTB_HUMAN (1-414): 0: 539: 35.66		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		737730 ACTG_HUMAN (1-414): 0: 538: 35.42		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		905825 ACTS_HUMAN (3-414): 0: 528: 35.59		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737734 ACTC_HUMAN (3-414): 0: 527: 35.59		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Sc
		696382 ACT_YEAST (1-414): 0: 528: 34.94		PP12_YEAST (1-308): 0: 547: 81.49