HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0030027 - lamellipodium
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 292
+	Hs
		625278 ACTB_HUMAN (1-414): 0: 539: 35.66		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		625338 ACTG_HUMAN (1-414): 0: 538: 35.42		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		625343 ACTS_HUMAN (3-414): 0: 528: 35.59		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		841152 ACTG_HUMAN (1-414): 0: 538: 35.42		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Hs
		841156 ACTS_HUMAN (3-414): 0: 528: 35.59		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Hs
		841154 ACTC_HUMAN (3-414): 0: 527: 35.59		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24