HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: ARP5L (Q9BPX5)
Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)
Gene: ARPC5L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	24981860, 28514442, 34079125, 33961781, 26655834
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~P16-Arc
Common GO terms	GO:0005737 - cytoplasm GO:0005885 - Arp2/3 protein complex GO:0005925 - focal adhesion GO:0034314 - Arp2/3 complex-mediated actin nucleation GO:0051015 - actin filament binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 153
+	Hs
		1308638 ARP3B_HUMAN (1-418): 0: 580: 90.67		ARP5L_HUMAN (1-153): 1.54e-71: 213: 100.00
+	Hs
		181310 ARP3_HUMAN (1-418): 0: 588: 100.00		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Hs
		181357 ARP3B_HUMAN (1-418): 0: 580: 90.67		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Hs
		891995 ACTB_HUMAN (1-414): 0: 539: 35.66		ARP5L_HUMAN (1-153): 1.54e-71: 213: 100.00
+	Dm
		689669 ARP3_DROME (1-418): 0: 562: 80.62		Q9VQD8_DROME (1-149): 3.62e-62: 189: 48.67
+	Hs
		929987 ACTG_HUMAN (1-414): 0: 538: 35.42		ARP5L_HUMAN (1-153): 1.54e-71: 213: 100.00
+	Hs
		181314 ACTG_HUMAN (1-414): 0: 538: 35.42		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Sc
		775027 ARP3_YEAST (6-417): 1.14e-171: 489: 58.35		ARPC5_YEAST (6-153): 4.52e-51: 161: 29.03